(532) Relationship Between Blood Volume Measures and Cardiopulmonary Exercise Testing Performance in Advanced Heart Failure

PurposeDirect measurement of blood volume provides better assessment and guides management congestion in patients with heart failure (HF). The impact using surrogate measures from analysis (BVA) on cardiopulmonary responses to exercise HF is unknown.MethodsThis a prospective two-center study enrolling consecutive advanced who underwent test (CPET) invasive hemodynamic BVA. Total (TBV), red cell (RBCV) plasma (PV) were measured indicator dilution technique an I131-tagged albumin tracer. BVA reports absolute values %-deviation ideal values. Absolute indexed 70 kg weight. association between CPET parameters was assessed Pearson correlation.ResultsTotal 40 (mean age 54.7 years, 30% female, 53% African American, 33% HFrEF) included. Mean TBV, RBCV PV 4263 ± 807, 1586 443 2676 536 ml/70 respectively. peak oxygen consumption (VO2) 11.7 3.5 mL/kg/min % predicted maximal VO2 52.0 16.7 %. minute ventilation/carbon dioxide production (VE/VCO2) slope 35.0 9.8. Respiratory exchange ratio (RER) 1.03 0.16. There moderate correlation (r=0.340, p=0.03). We observed VE/VCO2 TBV (r=0.333, p=0.04), (r=0.355, p=0.02) %deviation (r=0.323, p=0.04). no or RER.ConclusionHigher degree by associated worse but not other HF. HF-related clinical outcomes warrants further investigation. Direct unknown. This correlation. RER. Higher